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Find commanders that match how you play

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    Two-Color Guilds

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Best Infect Commanders for EDH

Infect decks are for players who want life totals to matter less than reaching ten poison on each opponent. This strategy wants to connect with infect and toxic creatures, using pump spells, evasion, protection, and infect commanders, to win through poison counter decks EDH opponents have to answer early. In the Counters, Proliferate, and Infect overlap, Counters grows creatures, Proliferate multiplies many counter types, and Infect is the poison win condition that proliferate can accelerate. The social cost is real: once poison appears, the table often treats you as the first threat, and some pods restrict the mechanic before deck selection.

Best Colors for Infect Decks

B mana
G mana

Golgari pairs dense infect creatures with green pump, black removal, and recursion for lost threats.

U mana
G mana

Simic adds unblockable effects, card draw, and proliferate engines that advance poison after contact.

W mana
B mana
G mana

Abzan blends toxic commanders, corrupted payoffs, white protection, black removal, and green pump.

How Do Infect Decks Win in Commander?

Infect decks excel through a specific playstyle and win conditions. Here's how they work:

✓ You attack early with infect and toxic creatures that deal poison instead of regular damage.

✓ You pump an evasive attacker so ten poison can arrive in one or two hits.

✓ You use proliferate to move existing poison counters toward lethal without another attack.

✓ You protect the key swing because one removal spell can erase the turn.

✓ You plan around the table turning on you as soon as poison appears.

Best Cards for Infect EDH Decks

Skithiryx, the Blight Dragon

Flying, haste, and self-pump let it threaten ten poison with protection.

Blightsteel Colossus

An infect trampler that removes a player with one clean combat hit.

Triumph of the Hordes

Gives your board infect and trample, converting combat damage into poison.

Inkmoth Nexus

A land that becomes a flying infect attacker and dodges sorcery-speed sweepers.

Grafted Exoskeleton

Turns any creature, including your commander, into a poison threat.

How to Build a Infect Commander Deck

Core Components

  • ✓Run 15-20 infect or toxic creatures, favoring evasion like flying, trample, or unblockable
  • ✓Include 6-10 cheap pump spells such as Groundswell, Might of Old Krosa, or Berserk
  • ✓Add 5-8 proliferate effects like Evolution Sage, Tezzeret's Gambit, or Contagion Engine
  • ✓Pack 6-8 protection spells because poison attackers draw removal immediately

The Ten-Poison Plan

  • ✓Ten poison eliminates a player regardless of life total, so lifegain does not change the clock
  • ✓One connected hit plus proliferate turns can finish a player without more combat
  • ✓Multiplayer means three opponents at ten poison each, so spreading counters matters
  • ✓Inkmoth Nexus and manlands keep threats available after board wipes

Surviving the Table

  • ✓Expect focused removal and early attacks once the first poison counter lands
  • ✓Sequence so you threaten lethal before slowly handing out warning counters
  • ✓Use Triumph of the Hordes to convert any creature board into a poison finish
  • ✓Have the rule-zero conversation before game one because some pods house-rule poison

Weaknesses of Infect Decks

  • ⚠Infect draws immediate table aggression, and playing one against three from turn two is a real cost of the archetype.
  • ⚠Dedicated infect creatures have weak stats for their cost, so the deck can struggle when poison stalls.
  • ⚠The strategy leans on combat, making it vulnerable to fog effects, deathtouch blockers, and repeated board wipes.
  • ⚠Some playgroups house-rule against poison entirely, so the deck may not be welcome at every table.

Is Infect Right for You?

Infect is mechanically simple and can be inexpensive, but it has a higher social cost than most combat decks. It suits players who enjoy racing under pressure and accept that one poison counter can reshape the whole table's threat assessment. Check with your pod first because the rule-zero conversation is part of playing poison.

Related Commander Strategies

Proliferate

Proliferate multiplies counters broadly; Infect uses it to advance poison.

Aggro

Aggro deals life-total damage; Infect races each opponent to ten poison.

Voltron

Voltron aims for commander damage; Infect needs ten poison per player.

Browse Commander Lists

Top Infect CommandersProliferateExtra Combats

Top Infect Commanders

Atraxa, Praetors' Voice

Atraxa, Praetors' Voice

B mana
G mana
U mana
W mana
MV: 4
InfectPlaneswalkers+1/+1 Counters+7 more
$33.41TCGPlayer
€19.30CardMarket
Ixhel, Scion of Atraxa

Ixhel, Scion of Atraxa

B mana
G mana
W mana
MV: 4
InfectPhyrexiansProliferate+7 more
$3.26TCGPlayer
€0.86CardMarket
Fynn, the Fangbearer

Fynn, the Fangbearer

G mana
MV: 2
DeathtouchInfectAggro+7 more
$0.19TCGPlayer
€0.17CardMarket
Vishgraz, the Doomhive

Vishgraz, the Doomhive

B mana
G mana
W mana
MV: 5
InfectPhyrexiansTokens+7 more
$1.87TCGPlayer
€0.58CardMarket
Skithiryx, the Blight Dragon

Skithiryx, the Blight Dragon

B mana
MV: 5
InfectVoltronEquipment+7 more
$11.12TCGPlayer
€8.35CardMarket
Brimaz, Blight of Oreskos

Brimaz, Blight of Oreskos

B mana
W mana
MV: 4
PhyrexiansInfectTokens+7 more
$0.52TCGPlayer
€0.44CardMarket
Karumonix, the Rat King

Karumonix, the Rat King

B mana
MV: 3
RatsRat ColonyInfect+7 more
$1.16TCGPlayer
€0.52CardMarket
Venser, Corpse Puppet

Venser, Corpse Puppet

B mana
U mana
MV: 2
InfectProliferateArtifacts+7 more
$0.31TCGPlayer
€0.15CardMarket
Atraxa, Grand Unifier

Atraxa, Grand Unifier

B mana
G mana
U mana
W mana
MV: 7
BlinkComboInfect+7 more
$16.25TCGPlayer
€18.31CardMarket
Skrelv, Defector Mite

Skrelv, Defector Mite

W mana
MV: 1
InfectPhyrexiansTokens+7 more
$3.04TCGPlayer
€2.91CardMarket
Kilo, Apogee Mind

Kilo, Apogee Mind

R mana
U mana
W mana
MV: 3
Artifacts+1/+1 CountersProliferate+7 more
$1.38TCGPlayer
€0.74CardMarket
Agent Frank Horrigan

Agent Frank Horrigan

B mana
G mana
MV: 7Universes Beyond
Infect+1/+1 CountersProliferate+7 more
$6.34TCGPlayer
€7.60CardMarket
Xavier Sal, Infested Captain

Xavier Sal, Infested Captain

B mana
G mana
U mana
MV: 3
PlaneswalkersTokens+1/+1 Counters+7 more
$1.67TCGPlayer
€0.98CardMarket
High Perfect Morcant

High Perfect Morcant

B mana
G mana
MV: 4
-1/-1 CountersElvesTokens+7 more
$1.20TCGPlayer
€1.22CardMarket
Ria Ivor, Bane of Bladehold

Ria Ivor, Bane of Bladehold

B mana
W mana
MV: 4
InfectTokensPhyrexians+7 more
$0.36TCGPlayer
€0.17CardMarket
Ezuri, Stalker of Spheres

Ezuri, Stalker of Spheres

G mana
U mana
MV: 4
+1/+1 CountersInfectProliferate+7 more
$0.82TCGPlayer
€0.48CardMarket
Tekuthal, Inquiry Dominus

Tekuthal, Inquiry Dominus

U mana
MV: 4
PlaneswalkersInfectProliferate+7 more
$1.24TCGPlayer
€1.60CardMarket
Hapatra, Vizier of Poisons

Hapatra, Vizier of Poisons

B mana
G mana
MV: 2
-1/-1 CountersTokensInfect+7 more
$0.31TCGPlayer
€0.33CardMarket
Tetsuko Umezawa, Fugitive

Tetsuko Umezawa, Fugitive

U mana
MV: 2
InfectWheelsAggro+7 more
$0.14TCGPlayer
€0.16CardMarket
Ezuri, Claw of Progress

Ezuri, Claw of Progress

G mana
U mana
MV: 4
+1/+1 CountersInfectElves+7 more
$1.71TCGPlayer
€1.10CardMarket
Glissa, Herald of Predation

Glissa, Herald of Predation

B mana
G mana
MV: 5
InfectPhyrexians+1/+1 Counters+7 more
$0.38TCGPlayer
€0.19CardMarket
Jon Irenicus, Shattered One

Jon Irenicus, Shattered One

B mana
U mana
MV: 4
DonateForced CombatStompy+7 more
$0.32TCGPlayer
€0.22CardMarket
Volrath, the Shapestealer

Volrath, the Shapestealer

B mana
G mana
U mana
MV: 5
-1/-1 CountersClones+1/+1 Counters+7 more
N/ATCGPlayer
N/ACardMarket
Toxrill, the Corrosive

Toxrill, the Corrosive

B mana
U mana
MV: 7
-1/-1 CountersControlInfect+7 more
$17.11TCGPlayer
€15.86CardMarket
Etali, Primal Conqueror // Etali, Primal Sickness
Etali, Primal Conqueror // Etali, Primal Sickness (back)

Etali, Primal Conqueror // Etali, Primal Sickness

G mana
R mana
MV: 7
ClonesComboRamp+7 more
$34.86TCGPlayer
€19.92CardMarket
Filter and browse all Infect commanders →

Frequently Asked Questions

What makes a good Infect commander?

The best infect commanders typically provide consistent access to the strategy's core mechanics. Look for commanders that you attack early with infect and toxic creatures that deal poison instead of regular damage.

How do Infect decks win?

Infect decks win through a combination of Skithiryx, the Blight Dragon, Blightsteel Colossus, Triumph of the Hordes, and other synergistic pieces that infect decks are for players who want life totals to matter less than reaching ten poison on each opponent.

What are the best colors for Infect?

Golgari pairs dense infect creatures with green pump, black removal, and recursion for lost threats. However, Simic adds unblockable effects, card draw, and proliferate engines that advance poison after contact.

What are the weaknesses of Infect decks?

Infect draws immediate table aggression, and playing one against three from turn two is a real cost of the archetype. Dedicated infect creatures have weak stats for their cost, so the deck can struggle when poison stalls. The strategy leans on combat, making it vulnerable to fog effects, deathtouch blockers, and repeated board wipes. Some playgroups house-rule against poison entirely, so the deck may not be welcome at every table.

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